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In particular a recent study by Shyti et al., [191] identified metabolic changes by mass spectrometry in a transgenic mouse model of hemiplegic migraine after experimentally induced CSD [207].
Although classic studies showed an improvement in high-fat-induced metabolic changes by EAA supplementation in rodents [22], these findings have not been translated into practical measures for counteracting the growing tide of health problems associated with obesity and metabolic syndrome.
There is also a connection to metabolic changes by GFPT1, PDXK, FBP1, ALDH6A1 and AZGP1.
A search for possible cis-acting consensus motifs in the regulatory region upstream SDH1-ORF revealed a dozen of upstream motifs that might respond to induced metabolic changes by altering the expression of Flx1p.
The aim of this study was to compare myocardial metabolic changes by direct measurements of substrates, such as glucose, lactate and pyruvate, using microdialysis (MD) in in-vivo porcine endotoxemic and hemorrhagic shock.
To explore associations between FDG-PET metabolic changes by SUVmax and clinical outcome (PFS), point estimates, and 95% CIs were calculated for median PFS for metabolic responders and nonresponders using Kaplan Meier methodology.
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Compound 8 underwent only a slight metabolic change by the human liver microsomes (HLMs), and also did not affect the activity of human cytochrome P450 isoform, CYP3A4, in the in vitro assays.
It would be of interest, therefore, to investigate whether the effect on neuronal survival and reduced vacuolation shown here is mediated by metabolic changes induced by a phenotypic shift of astrocytes.
In this study, we further explored metabolic changes induced by rotenone by analyzing its effects on intracellular levels of various short chain acyl-CoA thioesters, which are known to be involved in a number of metabolic pathways.
In conclusion, our findings support the concept that metabolic changes elicited by everolimus and visualised by PET are closely linked with the antitumour activity of the mTOR inhibitor everolimus.
The differential magnitudes (as shown by CNA) of the metabolic changes undergone by the two cultivars exposed to water deficit likely reflect corresponding differences in water stress tolerance.
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