For example, if a compound is bioactivated by phase 1 or 2 enzymes in vivo to a reactive metabolite before causing hepatotoxicity, then most HTS systems, which typically are deficient in these metabolic capabilities, will not be suitable for identifying these types of toxic events.
For example, we have learned that newborn and young rodents have significant age-dependent differences in metabolic capabilities, resulting in their not being able to metabolize BPA as well as adult rodents do and thus being exposed to higher levels internally; this is not the case for nonhuman primates (Doerge et al. 2010).
Recently, advances in synthetic biology have allowed us to perform more advanced systems metabolic engineering by creating novel biological systems, empowering microorganisms to gain new metabolic capabilities, which they otherwise might not have obtained naturally.
The G. metallireducens metabolic model contains many additional reactions reflecting these specific metabolic capabilities that the G. sulfurreducens model does not have.
As particular cells in the human body do not use all the metabolic capabilities encoded on the genome, procedures have been developed to tailor Recon 1 to tissue and cell specific functions [ 6- 8].
Wouldn't "favour new functions or metabolic capabilities" be equally clear?
In this particular case, knowledge of the metabolic network alone is not quite sufficient to predict the metabolic capabilities of a cell.
The small linear chromosome with large terminal inverted repeats and covalently closed hairpin ends, the extremely low GC content and the limited metabolic capabilities reflect unique features of ' Ca. P. mali', not only within phytoplasmas, but all mycoplasmas.
However, these two models did not provide the whole-cell characteristics and metabolic capabilities of S. platensis.
Therefore, it was not surprising that S. amnii, with its "reduced" metabolic capabilities, still effectively utilizes glycogen but can ferment only a few alternative carbon sources.
