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We hypothesized that, during hypercapnia, THAM infusion would keep pH normal by increasing the metabolic base component, would prevent increase of PVR, and would not increase lung injury.
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Many of the tuberculosis treatment drugs have metabolic targets [ 1] and a use of this metabolic based reconstruction can be to assist in identifying new and alternative chemotherapy targets for tuberculosis.
These results suggest that the high level of insecticide resistance found in Ae. aegypti mosquitoes from Martinique island is the consequence of both target-site and metabolic based resistance mechanisms.
A potential metabolic engineering target for altering NADPH metabolism based on metabolic flux analysis is discussed.
Basal metabolic acid base balance was defined as venous pH 7.37, which according to Siggaard-Andersen [ 11] yields a base excess of zero.
After the investigation period, a metabolic alkalosis (base excess levels > +5 mmol/l) was present in 55 calves.
He showed metabolic acidosis (base excess was -12.3, pH 7.28, HCO3 14.9) and plasma sodium was high 165 mmol/l.
Ethanol metabolic yield (based on hydrolyzed glucan and xylan) and ethanol yield (based on glucan and xylan in untreated CS) were 77 and 57 %, respectively.
Based on the physical-chemical approach, more than one metabolic acid-base disorder at the same time was found to be common in critical illness [ 11].
Ischemia may cause the metabolic shift, based on the well-known observations that anaerobic metabolism was associated with an increased glycolysis [3].
Six patients experienced a partial metabolic response based on FDG-PET criteria.
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