Many of these genes were involved in energy metabolism, implicating a rapid liver molecular reprogramming as critical for the metabolic adjustments to an acute stressor.
He proposed that sir-2 and its counterpart genes in animals were the mediators of caloric restriction: the genes sense when the body is running low on nutrients and direct a wide range of metabolic adjustments, from preserving tissues to burning off fat reserves.
Overall, the suppressed growth and metabolic adjustments during flooding confers a higher recovery rate to Sub1 plants compared to non-Sub1 plants as illustrated in the aerial photo of the IRRI demonstration plot (Additional file 1: Figure S1b).
In this study, 13C-metabolic flux analysis was used to characterize two violacein-producing E. coli strains with vastly different productivities, and to profile their metabolic adjustments resulting from external perturbations during fermentation.
As liver is the major target organ for metabolic adjustments, we exploited a selective transcriptomics approach to address molecular response in this tissue during acute stress adaptation in rainbow trout.
The effect of gene deletions on the flux distributions in the metabolic model of S. cerevisiae was assessed using OptGene as the modeling framework and minimization of metabolic adjustments (MOMA) as objective function.
During signaling, JA interacts, either synergistically or antagonistically, with other hormones, such as salicylic acid (SA), gibberellin (GA), ethylene (ET), auxin, brassinosteroid (BR), and abscisic acid (ABA), to regulate gene expression in regulatory networks, conferring physiological and metabolic adjustments in plants.
Even though some aspects of diapause are well investigated, broader scale studies that elucidate the global metabolic adjustments required for this remarkable trait, are rare.
In insects, diapause requires an array of sophisticated metabolic adjustments and can appear during development (developmental diapause) and adulthood (reproductive diapause).
Simultaneous identification of multiple metabolites, and information about their coexistence within a single pathway can provide clues about the relationship between development or environmental interactions, and the metabolic adjustments that accompany such events.
The data presented here support the hypothesis that the homeostatic imbalance between cell loss and cell renewal underlies premature aging in the XpdTTD mice through a complex interplay between cellular responses and compensatory metabolic adjustments to increased genotoxic stress.
