However, the theory of Minimization of Metabolic Adjustment (MOMA) suggested that when a severe perturbation occurred, the system adjusted itself to some extent towards a state that was close to normal [ 16].
Jensen and Papin further improved this mode of analysis by developing the Metabolic Adjustment by Differential Expression (MADE) methodology [ 30].
Recently, a new developed strategy combining flux balance analysis (FBA) and minimization of metabolic adjustment (MOMA) [ 12] would allow the comprehensive prediction for redox modulation in isobutanol production by simultaneously simulating the three redox reaction engineering methods.
This paper proposes a hybrid of the artificial bee colony (ABC) algorithm and the minimisation of metabolic adjustment (MOMA) to predict an optimal set of solutions in order to optimise the production rate of succinate and lactate.
Finally, 30 genes were identified as potential targets for DHA over-production using a Minimization of Metabolic Adjustment algorithm.
The roles of acetyl-CoA and NADPH in the regulation of PUFA biosynthesis were probed, and important genes and reactions were systematically analyzed using FBA, flux variability analysis (FVA), and minimization of metabolic adjustment (MOMA).
After validating under different cultural conditions, lots of targets were predicted successfully with help of Minimization of Metabolic Adjustment (MOMA).
A popular alternative method for predicting mutant behavior is based on the Minimization of Metabolic Adjustment (MOMA) [ 15].
To this end, OptGene algorithm [ 37] was used together with Minimization Of Metabolic Adjustment (MOMA) [ 17] as a biological objective function.
The full list of drugs in each group is reported in the Additional file 2. FBA: Flux Balance Analysis; MOMA: Minimization of Metabolic Adjustment.
FBA: Flux-Balance Analysis; MOMA: Method of Minimization of Metabolic Adjustment; SA: Synthetic accessibility; NR: a value not reported in the cited reference.
