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This cellular fate includes another metabolic adaption.
We note that this phenomenon is a distinct metabolic adaption that differs from the well-known 'flare' phenomena observed by FDG-PET during the initial growth of tumors and 'inflammatory flare', which occurs during infection or T-cell activation [30].
Studies on various biosynthetic pathways in fungi propose that HGT has played an important role in the evolution of fungal genomes, and more generally in metabolic adaption in eukaryotes [44], [45].
Under hypoxic conditions HIF-1α is stabilised, and this results in the transcriptional induction of hypoxia-responsive genes encoding proteins that will promote O2 delivery (VEGF, erythropoietin) and mediate metabolic adaption to reduced O2 availability (glucose transporter-1, glycolytic enzymes) [12].
Another metabolic adaption is the potential degradation of aromatic diterpenes encoded in the F113 genome.
These mice go through a crisis with overall weakness at weaning [38] indicating that ACBP is important for metabolic adaption which might also include regulation of lipolysis.
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Fasting induces specific molecular and metabolic adaptions in most organisms.
43 44 Moreover, physical activity counters weight loss-induced metabolic adaptions that facilitate weight regain 45 and reorganises the set point of nutritional balance.
The cellular adaption of WAT to adiposity is accompanied by major changes in gene expression reflecting both metabolic adaptions of the fat cells, and changes in the tissue as a whole, e.g., fibrosis and inflammation [ 5, 6].
4. Metabolic adaptation persists over time.
Maintenance of metabolic homeostasis requires adaption of gene regulation to the cellular energy state via transcriptional regulators.
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