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During septic shock, the Th pattern of T lymphocytes shifts, which can be regarded as a metabolic adaptation as it is mediated in part by adrenergic stimulation [8].

The concept of cellular metabolic adaptation as a necessary step for functional cellular reprogramming was first described by Otto Warburg in 1924 (Warburg, 1956; Warburg et al., 1924).

Briefly, male and female adolescent participants exhibited comparable increases in HR and similar metabolic adaptation as pH, HCO3 -, lactate levels and the respiratory ratio (RQ) [ 22].

Metabolic functions dominate among the 26 that do have putative annotations, including several peptidases, desulfoferredoxin, fructokinase, cartenoid isomerase and rubrerythrin (Additional file 6), suggesting metabolic adaptation as a selection force for their maintenance in the S. barkhanus genome.

12 15 Conversely, neither liver nor skeletal muscle showed major metabolic modulations besides an increased TNFα mRNA concentration in HFD-D mice, suggesting that these organs do not play a pivotal role during metabolic adaptation as an early event shaping the metabolic phenotypes.

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This parallels with 38% of EMs repeatedly selected in at least two independent experiments (pooling together different phases within each culture), from which we can conclude that cells experience as much metabolic adaptation during culture as between cultures with different pre-set conditions.

The significance of the TCA cycle in metabolic adaptation and as a signaling network is only now beginning to emerge [40], [41].

mhtt has been shown to inhibit the interactions of CREB and transcription initiation factor TFIID subunit 4 (toF4) to reduce expression of genes involved in metabolic adaptation such as PGC-1α (Cui et al, 2006), a transcriptional coactivator that induces the expression of a number of genes, including cytochrome c, to compensate for metabolic stress (Herzig et al, 2000).

There is now evidence that muscle recovery growth results from processes of metabolic adaptation, regulated by endocrine as well as the autocrine/paracrine system notably involving IGF1 [ 1, 5, 6].

Cisplatin treatment leads to immediate as well as delayed metabolic adaptations (measured as respiration and acidification) and changes in cell cell interaction and adhesion (measured as impedance).

There will be a better understanding of the metabolic nature of acute illness as well as metabolic adaptation from subcellular to organ-system levels.

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