Sentence examples for metabolic activation for from inspiring English sources

Other significant changes include a peak in activity in the absence of metabolic activation for YG1042 and TA98 on Day 24; this peak was not apparent with YG1041 (Fig. 1).

As dacarbazine requires metabolic activation for conversion to a methylating species, interpatient differences in metabolism will influence initial methylation levels, potentially confounding any correlation between MPG activity and 7-meG.

Some of the most-potent carcinogens for humans are the polycyclic aromatic hydrocarbons, which require metabolic activation for becoming reactive.

Unless we consider a so-called pro-drug, which requires metabolic activation for achieving efficacy, an otherwise unstable compound usually undergoes attrition during the drug development.

In experiments with metabolic activation, for strain TA98, the mutagenicity of B[ a]P was significantly reduced by 59%;.

Hepatic N-oxidation, followed by N-glucuronidation, has been proposed as a route of metabolic activation for arylamine bladder carcinogens.

However, if the concentration of LCA continues to rise, the percentage activation of PXR will also increase, leading to increased metabolic activation of, for example, CYP3A1, plus the activation of specific target genes geared towards meeting the response to cholestatic injury.

However, the S9 mix usually applied for metabolic activation of chemicals is toxic for ESCs and respective experiments have failed so far.

Yet, light sensitive ion channels may still be used to initiate intracellular events reminiscent of the metabolic activation of astrocytes (for example, release of Ca2+ from intracellular stores or increase in cAMP or glycogenolysis) or to trigger the release of signalling molecules from astrocytes, such as ATP [4], glutamate [2,5 7] or l-lactate [8].

The observed changes demonstrate tissue specificity in xenobiotic metabolism, with likely implications for the metabolic activation of procarcinogens to ultimate carcinogens of tobacco smoke.

Liver extracts from methylcholanthrene-induced rats were used for metabolic activation of the investigated compounds, and it was confirmed that HMF is not a mutagen.