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My laboratory has developed an original in vivo screening platform t to identify novel hormones that influence the behaviors (excess caloric consumption, deficient exercise and disrupted sleep-wake cycles) and the metabolic abnormalities caused by obesity.
The metabolic abnormalities caused by diabetes induce vascular dysfunction that predispose these patients to developing atherosclerosis [14].
Overall, these data showed that curcumin could improve the behavioral and brain glucose metabolic abnormalities caused by CUS, suggesting that curcumin might have an antidepressive effect.
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The mechanisms by which these metabolic abnormalities cause cardiovascular disease are not clear.
Metabolic abnormalities have historically been cited as the primary cause of pediatric nephrolithiasis; however, dietary and other factors such as obesity have also been studied with mixed results.
5 These metabolic abnormalities are caused by both humoral inflammatory mediators (such as cytokines) and of tumor origin.
Without treatment, these metabolic abnormalities can cause severe wasting of the body tissues and death.
Sleep deprivation causes metabolic abnormalities; short sleep causes insulin resistance and, possibly, overweight (12, 13) Turek predicted that coming research will show relationships of sleep abnormalities to CVD, cancer, gastrointestinal illness, attention deficit, and depression, and he showed his study of weekly reversal of the light-dark cycle increasing mortality in a CVD model (14).
Hult et al. now show that expression of mutant htt in the hypothalamus – a brain region central to regulating metabolism – causes metabolic abnormalities.
Primary HCM is characterised by concentric myocardial hypertrophy, i.e. increased wall thickness with normal or decreased chamber inner dimensions, primarily of the left ventricle, in the absence of other cardiac, systemic or metabolic abnormalities which may cause myocardial hypertrophy [ 2, 3].
Thus, it is possible that the thalamic lesions of pusher patients indeed cause functional or metabolic abnormalities in cortical areas via diaschisis [19], [21] or through vascular dysfunction, and that these (distant) functional abnormalities cause the patients' misperception of body orientation.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com