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AMPK was inactivated both in the in vitro and in vivo models of SOD1-linked ALS, suggesting that metabolic aberration is involved in the disease and that CysC possibly contributes to restore intracellular metabolic homeostasis.
One element that has surfaced from these studies is that the Stewart methodology is a precise and readily utilizable means of identifying the nature of the metabolic aberration; a calculator to determine the individual components is downloadable from the Internet [ 43].
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Genetic testing can unambiguously characterize fundamental alterations of the genetic code that give rise to metabolic aberrations.
Shortly after, numerous molecular studies showed that the endometrium in endometriosis and adenomyosis is characterized by impaired cellular responses to ovarian sex steroids [9], as well as by a number of other metabolic aberrations.
Disorders of the nervous system may be caused by trauma, infectious agents, toxins, metabolic aberrations, and also genetic defects.
Although the mechanisms of the purine metabolic aberrations are well understood, the mechanisms by which they lead to neural dysfunction are poorly understood.
Schizophrenia is a multifactorial disorder with strong genetic vulnerability and the vulnerability might include metabolic aberrations.
Several factors, including infection, are thought to precipitate these metabolic aberrations.
As a result, its deficiency can result in various metabolic aberrations [ 26].
Few previous studies of metabolic aberrations and prostate cancer risk have taken into account the fact that men with metabolic aberrations have an increased risk of death from causes other than prostate cancer.
Individuals with type 2 diabetes have a myriad of metabolic aberrations including increased inflammation, increasing their cardiovascular risk.
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