For Meta-UP, the procedure resulted in networks consisting of 476 nodes and 477 edges.
Therefore, no significant enrichment of conjoint pathways between Meta-UP and SEREX-ovarian datasets was noted.
The Meta-UP dataset contained 86 genes, ranked by reported literature frequency of differential expression.
The number of shared motifs in the SEREX-ovarian dataset is lower than that in the Meta-UP collection, although comparable numbers of sequences were analyzed (81 in SEREX-ovarian and 86 in Meta-UP).
We included all sequences from the Meta-UP dataset which were reported as upregulated in at least three publications (as distinct from the two reports required for membership in the Meta-UP dataset used in earlier analyses).
Nine of 46 pathways were identified as jointly populated by entries from the Meta-UP and SEREX-ovarian datasets.
We additionally constructed an interaction network based on genes stored in Meta-UP including (previously predicted) enriched transcription factors.
We further included three sequences listed in Meta-UP which were also reported in the SEREX-ovarian dataset.
First, the regulatory regions of genes stored in the datasets Meta-UP and SEREX-ovarian were extracted.
The GO analysis results contain the enriched GO terms for the meta-up- and the meta-downregulated genes, respectively.
Amongst the 192 genes, 86 were reported as upregulated (Meta-UP) and 106 as downregulated (Meta-DOWN).
