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Statistical analyses were undertaken using the R Software with the SNPassoc and Meta packages (http://www.r-project.org/).org/
The Mantel-Haenszel χ test and estimate of the OR were computed with or without the inclusion of covariates using R, version 3.0.2, with the "metafor" and "meta" packages.
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Meta analysis of studied populations was performed in R (meta package) using inverse variance method with a fixed effect model.
Meta-analysis was performed using the "Meta" package, with fixed effects and continuous outcome data.
22 We used the "meta" package in R version 3.0.2 (R Foundation for Statistical Computing, Vienna, Austria) to perform meta-analyses.
All analyses were performed using the meta package within R statistical software [ 9].
We used the metabin option from the meta package of the R software to perform the meta-analysis.
For mathematical reasons, cells with zero frequencies were assumed to be 0.5 (as defaulted by the meta package).
We analyzed the data set using a random effects meta-analysis, using the metagen function within the meta package of r (R Development Core Team 2013; Schwarzer 2013).
We carried out a confirmatory analysis using the "meta" package of R software (R version 2.13.0, R Foundation for Statistical Computing) and arcsine transformation.
All calculations were performed using R version 2.3.1 (The R Project for Statistical Computing, www.r-project.org) and the meta package (G. Schwarzer, cran.r-project.org).org
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