This dissimilarity is used to define and detect consensus meta-modules, that is meta-modules present in all input eigengene networks.
The first meta-module consists of the red, black, and yellow eigengenes; the second meta-module contains the turquoise eigengene; and the third meta-module contains the pink, blue and brown eigengenes.
The third brain meta-module consists of the turquoise, green and purple eigengenes.
This meta-module is highly preserved in muscle and liver but less so in adipose.
The second brain meta-module consists of the green-yellow, pink and yellow consensus eigengenes.
Specifically, the first brain meta-module consists of the black, blue, magenta, and red consensus eigengenes.
The first meta-module (comprised of the black, yellow, and red module eigengenes) represents 270 genes that tend to be differentially expressed in the caudate nucleus.
The second meta-module (comprised only of the turquoise eigengene) represents 884 genes that tend to be differentially expressed in cerebellum.
The third meta-module (comprised of the pink, blue, and brown module eigengenes) represents 375 genes that are differentially expressed in the cortical samples.
Given the strong relationships between modules in each meta-module, it is natural to ask whether the consensus modules are truly distinct.
