Future CB-meta efforts need large numbers of studies for inclusion to enable more definitive conclusions, upon which models for the prediction or diagnosis of brain disorders can be developed.
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In addition, large-scale international meta-analysis efforts are underway and will ensure maximal GWAS sample size.
One approach is to continue the successful meta-analysis efforts thus far and increase the sample size and power.
The differential and lower level of LD in African Americans will likely greatly improve the fine mapping of causal variants in ongoing trans-ancestry meta-analysis efforts.
Importantly, it has also enabled the first-line use of imputation approaches (39) to infer genotypes at untyped low-frequency variants in large-scale GWAS meta-analysis efforts.
In studies where the data was presented in a non-numerical format, and thus not possible to include in a meta-analysis, efforts were made (by DG) to contact the author to obtain these data.
These methods have been used successfully by a few transethnic and large-scale meta-analysis efforts, although their applications have been thus far limited to a few publications [ 7, 14, 33, 56, 59].
Although association between the GDF5 locus and hip and knee osteoarthritis was first reported in a study of Japanese and Chinese individuals in 2007, 20 it took several years and large-scale meta-analysis efforts to replicate the association robustly in European populations.
There is now a need for a larger international meta-analysis effort that incorporates further datasets.
Even when tests are similar, and hypothesized to measure corresponding cognitive processes, they may still create a substantial source of heterogeneity for a meta-analysis effort.
