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Furthermore, they highlight the limitations of commercial RGs and indicate that meta-data analysis of genome-wide transcription profiling studies may identify new RGs.
In addition, we also pursued meta-data analysis of previously analyzed, non-diseased cortical samples to still further increase the "N" of non-diseased samples, towards better assessing statistical separation between non-diseased and diseased samples.
Furthermore our results pinpoint the limits of conventional RGs and suggest that relatively simple meta-data analysis of genome wide transcription profiling studies is a useful way of identifying putative RGs.
This meta-data analysis of over 200 arrays from diagnostic ALL samples with hyperdiploidy, T-cell lineage and translocation status (previously confirmed through gold standard techniques), shows that expression profiling as an integrated platform is robust and that ALL data, and presumably other disease models, can be interplatform comparable.
If a particular study was included in a meta-analysis or pooled data analysis of good or fair quality, we did not incorporate this study again in the synthesis of the evidence.
These are meta-data-analysis (the analysis of findings), meta-method (the analysis of methods) and meta-theory (the analysis of theory).
Although costly and time consuming compared with aggregated data meta-analysis, meta-analysis of individual patient data allows the most definitive synthesis of available data and should be promoted in research in reproductive health.
We therefore compared the results of our individual participant data meta-analysis of the data provided by Medtronic with meta-analyses of summary data extracted from the published literature and from the internal reports provided by the manufacturer.
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