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In short the company realized that for all its high talk of becoming a meta-box for all media everywhere, it was still in the games business.
This meta-box is the main controller of the simulation.
This meta-box is created to simulate water and Na+ intake.
The system "current state of the body fluid compartments" is composed of one meta-box called "body fluids".
It contains a digestive module and a motivation module making this meta-box the most complex of the model.
The effects of furosemide were simulated by substituting the regular kidney output of the model (see meta-box "kidney" above) by a computed furosemide output.
Finally, the system "controllers" is composed of one meta-box called "AVP secreting magnocellular neurons" and additional corrections for active natriuresis and/or Na+ retention.
Altogether, the body-fluid compartments are simulated by a meta-box that dynamically integrates three biological parameters: (1) the ECF volume, (2) the ECF [Na+] and (3) the ICF volume.
This meta-box is designed to dynamically simulate the rate of urine flow and the rate of Na+ excretion by the kidneys (passive Na+ clearance and active natriuresis or Na+ retention).
These differences mainly depend on the frequency and distribution of unregulated drinking in the simulation (see the meta-box "digestive system in methods) and illustrate the random nature of the daily fluid and electrolyte consumption of the rat.
Interestingly, substitution of the meta-box "vasopressin level" by a biologically inspired simulation of the magnocellular neuron network [ 45] in future versions of the simulation would allow us to predict how local modulation of neuronal excitability by osmotic challenges and drugs targeting these neurons would influence the dynamics of global homeostatic parameters in rats.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com