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The cyclic nucleotides, cAMP and cGMP, are important intracellular messengers that regulate multiple critical signaling pathways important in normal physiology, as well as pathogenesis of disease.
An important task of nanobiotechnology is to understand the effect these nanomaterials have to modulate expression of cytokines, which are soluble biological protein messengers that regulate the immune system.
Phosphoinositide 3-kinases (PI3Ks) generate lipid second messengers that regulate a broad variety of cellular responses such as growth, cell cycle progression, differentiation, vesicular traffic and cell migration [1].
Inositol pyrophosphates are phosphate-rich metabolic messengers that regulate many cellular processes.
Calcium ions and cyclic AMP are ubiquitous intracellular messengers that regulate a plethora of cellular processes.
They are messengers that regulate and bring information to the cells of the immune system [ 7].
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Although each method for analyzing Ca2+ has certain drawbacks it is now appreciated that Ca2+ signaling is regulated at the subcellular level, and that this level of regulation is necessary for Ca2+ to act as a second messenger that regulates multiple cell functions simultaneously.
Raucher, D. et al. Phosphatidylinositol 4,5-bisphosphate functions as a second messenger that regulates cytoskeleton-plasma membrane adhesion.
Inositol 1,4,5-trisphosphate (IP3) is a crucial second messenger that regulates complicated signaling processes in various physiological events.
d-myo-inositol 1,4,5-trisphosphate (Ins(1,4,5 P3, or IP3) is a ubiquitous second messenger that regulates cytosolic Ca2+ activities ([Ca2+]i).
Here we use optical tweezers tether force measurements and show that plasma membrane phosphatidylinositol 4,5-bisphosphate (PIP2) acts as a second messenger that regulates the adhesion energy between the cytoskeleton and the plasma membrane.
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