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In this work, the initiator was the observation that anti-apoptotic proteins rescue the effects of blocking Slug expression on mesodermal and neural crest markers.
Morpholino-based loss of function studies indicate that Slug is required for the normal expression of both mesodermal and neural crest markers in X. laevis.
The maxillary barbel contains a simple cylindrical assemblage of ectodermal, mesodermal and neural crest derivatives, including skin, glands, pigment cells, taste buds, sensory neurons, blood vessels and a putative lymphatic.
This is also the case with the Slug morpholino; injection of 500 pg/embryo Snail RNA rescued expression of both mesodermal and neural crest markers in Slug MO injected embryos (FIG. 1J L; Table 1).
SKPs were initially derived from neural crest and displayed multidirectional differentiation capacity including mesodermal and neural progeny during long-term culture [ 24].
Platelet-derived growth factor receptor alpha (Pdgfrα) is required in mesodermal and neural crest-derived mesenchyme during development (Schatteman et al., 1992; Soriano, 1997).
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Then, cephalic mesodermal cells and neural crest cells expand ventrally at the same time into the future branchial arch region.
Activation of Slug at stage 8 lead to a complete rescue of both mesodermal (Xbra) and neural crest/placodal (Sox9) marker expression.
Each PA is composed of a mesodermal core and neural crest cell derived mesenchymal cells that are surrounded by ectoderm outside and endoderm inside.
Both mesodermal cells and neural crest-derived cells are presumed to contribute in various proportions to the genesis of meningeal tissue [ 3].
Together, these observations reveal that sizzled, in addition to its established role in dorsal-ventral patterning, is also part of a dynamic BMP and Wnt signaling network involved in both mesodermal patterning and neural crest induction.
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mesodermal and endodermal
mesodermal and septum
mesodermal and pluripotent
mesodermal and neuroectodermal
mesodermal and extraembryonic
mesodermal and ectodermal
mesodermal and mesectodermal
mesodermal and neurectodermal
mesodermal and neuronal
mesodermal and spinal
mesodermal and epidermal
mesodermal and extra-embryonic
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