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Mesenchymal precursor cells in the periosteum differentiate into neochondrocytes, producing cartilage tissue during embryogenesis and contributing to bone apposition during intramembranous ossification by differentiating into osteoblasts [15].
Osteoconductive porous ceramic bone graft materials supplemented with mesenchymal precursor cells (MPC) derived from autologous bone marrow aspirates have been shown to stimulate successful interbody and posterolateral spine fusion in preclinical models.
Among these, bone morphogenetic proteins (BMPs) have the unique ability to stimulate the differentiation of mesenchymal precursor cells to chondrocytes and osteoblasts, and induce formation of new bone at both ectopic and orthotopic sites.
Overexpression of SRA in ST2 mesenchymal precursor cells promotes their differentiation into adipocytes.
The development of temporary cartilage involves the differentiation of mesenchymal precursor cells along the chondrogenic lineage.
Recent data on mesenchymal precursor cells from the peripheral blood, suggest a close relationship between FDCs and fibroblast-like cells [8].
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The murine KS483 cell line is a mesenchymal precursor cell line, which differentiates into mature mineralizing osteoblasts during a three-week culture period, when cultured under osteogenesis inducing conditions.
The prevailing model for the origins of this tumor is that a mesenchymal precursor cell undergoes a second genetic hit at one of the TSC loci, rendering the cell defective for TSC1-TSC2 complex function and, thereby, activating mTORC1.
The mouse Zfp191 has been previously isolated from chondrocytic and mesenchymal precursor cell lines using a subtractive hybridization screening.
This study was undertaken to determine whether the anti-osteoarthritis drug pentosan polysulfate (PPS) influenced mesenchymal precursor cell (MPC) proliferation and differentiation.
Given that adipocytes share a common mesenchymal precursor cell with osteoblasts, entrance into the adipocytic or osteoblastic lineage is thought to be mutually exclusive [ 26].
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