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"It's an interesting strategy, and it merits clinical testing," says Louis Weiner, a medical oncologist at Fox Chase Cancer Center in Philadelphia, Pennsylvania.
Although the true activity of the various VEGFR inhibitors in GCTs remains to be demonstrated [ 37], we believe that pazopanib is potentially a new agent that merits clinical testing in CDDP-refractory GCT patients as a single agent or in combination with other therapies, such as ErbB-targeted therapies.
Similar(58)
Observational, open studies with well-chosen patients and an adequate design tailored to answer precise predefined questions (including go/no go criteria) are most valuable for experienced clinicians in determining the clinical benefit of the drug, and for the pharmaceutical company in assessing the commercial merit of proceeding with further clinical testing.
Further studies are merited to determine the role of clinical testing for p63 expression and/or TP63 rearrangements in CTCL and to investigate strategies to target these rearrangements therapeutically.
When we identify such molecules, we can start thinking about pre-clinical and clinical testing".
We then went into two years of clinical testing.
Multiple clinical testing proved this basic premise correct.
Clinical testing shows the product has proven that it works.
Further clinical testing is warranted.
Therefore, the combination of capecitabine with radiotherapy merits clinical investigation.
This suggests that the combination of bicalutamide and abiraterone merits clinical evaluation.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com