There are seven PKC isoforms, that is, α, βII, δ, η, ɛ, λ, ζ, which were shown to be expressed in A431 cells.78 To delineate which isoform(s) is responsible for Dsg3-mediated Ezrin activation merits further investigation.
In particular, the pathogenesis of HIV-1-related endothelial activation merits further investigation [ 7].
Whether the metformin ability to directly [ 48] or indirectly inhibit AMPD, such as through the accumulation of intermediates during the folate-dependent metabolism of one carbon unit [ 43], could counteract the longevity induced by AMPK activation certainly merits further exploration.
Further studies indicate that the most notable merit of δ-opioid receptor activation is to provide cardioprotection [ 10– 10].
We evaluated our experience to assess if intubation alone merited the highest level of trauma activation.
These in vitro observations suggest that combinations of proteinase inhibitors, particularly of uPA/plasminogen activation and MMPs, may merit clinical evaluation as potential antimetastatic therapy for breast cancer.
The role TGFβ in maintaining cell quiescence, GATA3/T-BET as master regulators of transcription of pro- and anti-inflammatory cytokines and BCL10 in NF-κB activation are intriguing and merit further investigation.
Our pilot results suggests that morphoproteomic assessment of signaling pathway activation in Ewing's sarcoma merits further investigation as a guide to understanding response and resistance signatures.
The review takes a critical look at the relative merits of therapies being developed to tackle inappropriate complement activation that are likely to result in sporadic autoimmune diseases or worsen already existing one.
Pharmacologic AMPK activation is a novel potential therapeutic approach for OA that merits further investigation.
The role of STAT3 in promoting transformation is well documented [ 3], yet the merit of our work was to link for the first time STAT3 activation to breast cancer relapse after surgery.
