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In addition, the Climate Prediction Center (CPC) Merged Analysis of Precipitation (CMAP) dataset (Xie and Arkin 1997), the horizontal spatial resolution of which is the same as the NCEP NCAR reanalysis dataset.
The sea surface temperature (SST) used was obtained from the NOAA Optimum Interpolation version 2 [29] while the precipitation data was retrieved from the Climate Prediction Center Merged Analysis Precipitation (CMAP) dataset [30].
The prospectively defined analysis plan was then executed on the merged analysis dataset.
This was paralleled by a merged analysis of specific gene categories (i.e. the AHD categories).
These genes seem to have been selected in the merged analysis due to the technical consistency on the microarray platforms allied to the larger pooled sample size.
Preliminary analysis found that the correlations between pigs in scores from separate or merged analyses were very high, indicating that the merged analysis did not alter the ranking of the pigs in the separate analyses.
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The merge analysis of the three QTLs suggested several candidate causal genes with significant merge SNPs nearby.
The merge analysis for Kprl1, 2 and 3 are shown in Figure 6A, B and C respectively.
The list of all potential causal variants identified by the merge analysis is presented in Additional file 2: Table S3.
By merge analysis, sunitinib and Lysotracker were found to highly colocalise in the majority of cells (yellow, Figure 5A), demonstrating a lysosomal sequestration of sunitinib.
This method is similar in spirit to merge analysis (Yalcin et al. 2005), which also uses genetic similarity to narrow QTL regions in multi-founder crosses.
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