Indeed, it remains highly controversial whether or not the mere elevation of extracellular D-glucose can directly promote vascular inflammation, which favors early pro-atherosclerotic events.
The mere elevation of extracellular D-glucose from 5.5 mmol/L up to 22 mmol/L did not alter the basal expression of both ICAM-1 and VCAM-1 in HUVEC after 18 h (107.05±4.4 and 104.5±3.7% of the expression observed with 5.5 mmol/L D-glucose, respectively. Figures 1C-1D).
There is a clear difficulty in using measures of fasting insulin as an estimate of insulin resistance in settings of glucose excursions, since the mere elevation of BG implies a limitation in secretion of adequate amounts of insulin to normalize BG.
With the merest eyebrow-elevation, or discontented moue, or sly disclosure of ripped abs, Redmayne rules this film.
Yet the route, an offshoot of the longer Lost Man Loop that begins at a mere 10,520-foot elevation, is only just over a mile round trip as it climbs about 500 feet to the lake -- just enough to wind a first-day hiker, but not so much as to cause heart palpitations.
"Soul Train" is receiving TV Land's Pop Culture Award, symbolizing its elevation from mere television show to cultural phenomenon.
Yet, in accordance with the elevation of mere men possessing sound coaching skills and savvy sales pitches to the level of certifiable campus god, we often understate administrative impact in the discussion of why some are great, some are good and some are Rutgers.
Made up of four interlinked resorts on the northern Japanese island of Hokkaido, Niseko's base elevation is a mere 300 metres, and the highest lift tops out at 1,200 metres, but it makes up for this with some of the most incredible powder snow imaginable – an average of 14 metres a year – and a plethora of off-piste and backcountry runs.
The trail up Bierstadt from Guanella Pass is a mere three miles with a 2,500-foot 2,500-footgain.
The rapid elevation of TCF7L2 from mere candidate to presidential status (a rise enabled by the availability of large sample sets from diverse populations and rapid, accurate genotyping), has meant that years of debate about the validity of TCF7L2 as a diabetes-susceptibility gene have been avoided.
Less clear than the mere fact that fusion triggers [Ca2+]c elevations, is the question of its origin: does Ca2+ come from the extracellular space exclusively, or also from the fusing LB?
