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For the determination of the mass eruption rate (MER), it is crucial to check whether a correlation exists between the time interval between two pulses and the transported mass.
In short peptides (<10 mer), it has been reported that only few amino acids (2 3) have a significant role in binding, and these kinds of short peptides can show some binding even after being scrambled [45].
Thus, the TAM receptors fall into two groups based on features of their ligand and PtdSer activation profiles: Tyro3 and Mer are activated by both Gas6 and Pros1, whereas Axl is activated only by Gas6; and while Gla-less Gas6 is a substantially weaker ligand for Tyro3 and Mer, it is effectively dead as a ligand for Axl.
Similar(56)
Mers, it now turns out, was lax and loose, as well as fast, in processing foreclosures.
Since sequence motifs and IT features are computationally expensive compared to k-mers, it would be extremely difficult to establish models for all pairs of species for automatic categorization.
A sequence is considered to contain a TSS on position +1 if for all 1,364 k-mers it satisfies all above constraint conditions.
To avoid highly repetitive k-mers, it dynamically tabulates a threshold M so that k-mers with more than M occurrences constitute at most 1% of all k-mer occurrences.
Finally, given the massive number of potential k-mers, it is crucially important to improve signal-to-noise ratio by focusing on the informative ones.
Because RNA-Skim uses a much smaller set of sig-mers, it is able to use the rolling hash method a very fast but memory-inefficient method to count sig-mers in RNA-Seq reads.
Because it is based on maximal overlaps, which are typically longer than de Bruijn k-mers, it also disambiguates shorter repeats that de Bruijn methods would only resolve in later processing steps (if at all).
As promoter regions get larger and encompass a greater variety of k-mers, it is more likely that important motifs will become lost in the background (i.e., less likely to stand out or discriminate between targets and non-targets).
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