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To obtain the information content (IC) score, every possible l - mer in each of the t sequences must be examined.
Only the highest scoring l - mer in each sequence is noted and kept as part of the alignment.
Furthermore, plots of Δ A340 nm as a function of Fe2+ ions per BFR showed clearly that the initial rapid oxidation phase saturates at two Fe2+ ions per subunit (∼50 per 24 mer) in each variant, as observed for the wild type protein.[ 4a] X-ray crystal structures were determined for the Y45F, Y114F, and Y149F variants (Supporting Information, Table S1, Figure S3).
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The concentration of 33-mer in each digest was determined from those digest dilutions yielding initial rates within the linear region of the 33-mer standard curve.
Levels of D933-mer in each sample were determined by comparison of the area under the D933-mer transition peak to the area under the internal standard transition peak.
Conversely, Simrank and BLAST examined each 7-mer in each query requiring more compute time but enabling distant similarity reporting.
H AMMER employs a simple and fast clustering technique based on selecting a central k-mer in each connected component of the Hamming graph.
The frequency of each octamer in the core genes was determined as the sum of the counts of the 8-mer in each core gene divided by the sum of their effective lengths (the length of each gene minus 7).
We test for each k-mer in each aligned read at genome position g, whether there is already a k-mer at g and whether the new k-mer can be joined with it.
The rows of the W matrix, which represent the frequency of occurrence for each k-mer in each motif, were compared with an exact count of the tetramers that were inserted as part of each motif (including those that span the motif-background boundary) using a Pearson's correlation.
From these sequences, we calculated the frequency of all possible l-mers in each gene.
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