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Going forward, the ability to reduce the above mentioned variability and to provide a sustained release of PRP biomolecules may be critical to expedited healing of bony defects.
In any case, given the mentioned variability and complexity of these tumours, a better understanding of their basic biology is required to define relevant targets for the development of novel therapeutic approaches.
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As previously mentioned, the variability of nitrate concentrations in Podravina was also recorded in some wells close to pollution.
The retention index, too, is affected by the mentioned AIF variability at late times due to the evoked changes of the TRF slope.
Finally, in addition to the genes mentioned above, variability in the presence of other virulence genes also supports the notion of a mixed STEC population.
The already mentioned high variability of gene order and the presence of duplicated genes (Ren et al. 2010; Passamonti et al. 2011; Okazaki M and Ueshima R, unpublished data) support the common occurrence of gene rearrangements in bivalve mitochondrial genomes.
(Note: in the previous task mentioned, FR4/0.5s variability – measured as cv – also decreased for frequency/IPIs, as shown in that study. Therefore the new task ran here is a more appropriate control for the questions raised by the reviewers).
It is interesting to mention the variability of the PD cases compared to the NPD ones.
Since there were zero false negatives, verification bias corrected confidence intervals cannot be derived (the authors did not provide confidence intervals, and did not mention the variability associated with the estimated sensitivity).
Given the fact that high-throughput datasets are inherently noisy (as mentioned above), the variability due to starting point is less significant.
This problem is compounded by the issue of patient variability mentioned earlier as it is easy to adhere to the treatment protocol with some patients whereas with others it is much more difficult.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com