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Examining the above mentioned trials with respect to early death rates, we obtained the information as shown in Table 3.
As mentioned, trials with too small sample sizes often show intervention effect sizes far from the effect sizes shown in larger trials and systematic reviews with meta-analyses [ 27, 35].
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Notwithstanding the mentioned trials, phase III trial demonstrated no superiority over standard chemotherapy for advanced or metastatic melanoma in patients who underwent treatment with tremelimumab.
Journals with higher IFs were more likely to mention trial registration explicitly (p=0.015).
Journals with higher IFs were more likely to mention trial registration.
Journals with high impact factors were more likely to mention trial registration.
Among the seven randomised trials mentioned, with the exception of the GRETA trial, all compared both treatment arms in terms of OS.
The stimulus duration was 100 ms with a pseudo-randomized inter-stimulus interval (ISI) of 2500 3500 ms to prevent anticipation in combination with the above mentioned catch trials.
A higher mean baseline Se intake was found in the six randomized controlled trials mentioned above, compared with our study.
As mentioned, these were all trials with osteoporotic patients with fragility fractures and, to our knowledge, our study has had the longest follow-up of treatment of OA patients with risedronate to be published so far.
Among the alternatives Thomas mentioned were trial by judge alone; a tribunal of a judge and two or more lay people; and trial by a judge sitting with assessors.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com