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Eight studies of poor methodological quality [24, 29, 45, 46, 55, 60, 72, 73] were limited by insufficient participant numbers to satisfy rating classification as fair in addition to four of the mentioned studies investigating acute responsiveness [41, 75 77], therefore not enabling assessment of longitudinal responsiveness.
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The above mentioned studies investigated effects of antidepressants on CREB without inducing stress.
Also, the present study and the above mentioned studies investigated rather young populations with mean age around forty years [ 3, 4, 8, 32].
Also, the above mentioned studies investigated only young adults, but it would also be important to examine brain processing during performance feedback among the older adults.
The above mentioned studies investigated the in vitro degradation behaviour of low-strength brushite cements, that is, having strengths lower than 15 MPa (24 hours after setting), with Cama et al. [ 9] being one exception (27.6 ± 3.3 MPa).
In comparison, in our study, a slightly smaller but more specific patient population was investigated, while the latter mentioned study investigated patients with nonspecific planar bone scan findings.
None of the above mentioned studies has investigated this explicitly.
This may also be one explanation for a higher estimate of treatment adequacy in our study compared to other previously mentioned studies: we investigated the most recent lifetime depressive episode whereas many other studies have looked at depressive episodes within the last 12 months.
However, as mentioned, outcome studies investigating the benefit of intervention are still lacking.
As mentioned previously, studies investigating the mechanisms of ethanol induction of proinflammatory genes in the brain have shown that chronic ethanol increases expression of TLRs as well as the TLR4 receptor agonist HMGB1.
The fore mentioned studies did not thoroughly investigate the rest of the genome, which may contain pertinent information for host response to PRRSV infection.
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CEO of Professional Science Editing for Scientists @ prosciediting.com