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Twelve mentioned studies from the scientific literature and 7 quoted "experts" directly.
Only recently, the mentioned studies from Brazil pointed to the fact that EC in the sugarcane spirit cachaça may be as problematic as from European fruit spirits, due to the cyanogenic nature of sugarcane materials, with hydrogen cyanide suspected as a major precursor of EC formation in both stone-fruit spirits and cachaça [ 18].
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This has been observed from both the previously mentioned study from New Delhi [ 25], and Chennai [ 3].
In a previously mentioned study from China, the OR for the highest vs the lowest quartile of soya protein intake was 0.67, with a significant trend in risk (P for trend 0.01; Xu et al, 2004).
This view runs contrary to a significant body of hydrological evidence from Spain (not to mention studies from comparable climates elsewhere in the world) that shows strong correlations between increased forest-cover and decreased water-supply (see for instance Buendia et al. 2016; Gallart and Llorens 2003).
Overall, the level of evidence for the mentioned studies ranged from 1b to 2b [ 36].
The concentrations of homeopathic remedies in the above mentioned studies ranged from 1x, 4x, 12x, 5c, 6c up to 1 M. Homeopathic remedies of Calendula and Hypericum applied were in the range of mother tincture (1x) in a rat model [ 33], but even Arnica 12x showed positive influence on wound healing in rats [ 32].
Pooled data from previously mentioned studies, including 258 patients from 2 blinded studies and 858 patients from 3 open-label trials, were reviewed for a change in serum electrolytes due to lubiprostone (24 μg bid) (Rivera et al 2007).
To the best of our knowledge, all of the mentioned studies analysed data from patients with brain tissue-specific tumours without including patients with BM.
Epidemiologic data on relevant covariates, previously obtained by questionnaire within each of the above mentioned studies, were extracted from existing databases and assembled.
Note that all expression measures for genes, miRNA and TF were acquired from marrow cells of the same patients, whereas the other mentioned studies relied on expression levels from multiple studies of different tissues.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com