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The previously mentioned randomized, controlled studies in blunt and penetrating trauma [ 16], which forms the basis for this analysis, have demonstrated no safety concerns when using rFVIIa in trauma patients.
The first two trials used glucocorticoid doses higher than any other trial in this review, with the exception of the previously mentioned randomized controlled trial in CNS neoplasms.
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17 Based on the encouraging clinical outcomes of the above mentioned phase II trials, a pivotal, randomized, controlled phase III trial conducted in Europe, Australia, and Canada was performed, in order to compare panitumumab 6 mg/kg intravenously every 2 weeks plus best supportive care (BSC) versus best supportive care alone.
Randomised controlled trial OR randomized controlled trial.
And as I mentioned recently, we are participating in a third-party, randomized controlled trial project.
It also is intriguing to note that reports of large multicenter, randomized, controlled trials assessing the impact of IIT make no mention of the tubing system used [1 4, 12].
A single blind randomized controlled trial will be performed at the three above mentioned centers.
Randomized, controlled, long-duration trials with independent adjudication are the only way to evaluate rare side effects, as also mentioned by Kahn recently (7).
RCT, randomized controlled trial.
To answer this question we needed randomized, controlled research.
Without randomized, controlled, prospective studies even age-old dogma and common-sense conclusions are suspect.
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