As expression dataset, we used the afore-mentioned published data [37], [40], ranked using the signal-to-noise metric.
As published data mention ZBTB2 recognition of p21 regulating sequences, we verified that this sequence specific binding was also alleviated by 5-hmC.
While all (13/13) respondents to the survey mentioned that their institutions take published data into account for coverage decisions (Additional file 6: Table S3), only seven (Czech Republic, Germany, Finland, France, Iceland, Poland, Sweden) explicitly stated that unpublished information is also considered.
Leaving aside for a posterior analysis those aspects related to the severity of ADR, the number of patients responding to treatment without suffering ADR is unavailable in most published data sources, as mentioned above.
Particularly for the Beagle, it should be mentioned that most of the earlier published data are based mainly on laboratory dog populations [ 117].
Our findings also contradict the published data, because, as mentioned above, only a reduction in MBD2 has been detected in human neoplasia (Kanai et al, 1999; Müller-Tidow et al, 2001; Billard et al, 2002).
Numerous review articles have been published mentioning fluocinolone therapy for DMO but there is a paucity of published data on use of fluocinolone 0.2 μg/day or iluvien® outside the experience of the FAME trial [ 8, 17].
Another technique, referred to as "stewing" wood has been mentioned whereby wood is boiled in different solutions to achieve alterations of density although there is no published data on what this process is actually doing to the wood.
The globally published data on recycled aggregate standards (normative documents) of various countries have been systematically analysed and evaluated, and some barriers mentioned.
Efficacy data mentioned in a positive list published by a society for hospital hygiene should still be regarded with caution if they quite obviously contradict published data on the same or similar products.
The following are mentioned as reasons: personal references, personal experience, and that reputation and recommendation of an institution from the family doctor would be more heavily weighed than published data [ 3, 4, 9- 11].
