The corpus consists of 130 Medline abstracts mentioning proteins and genes, with a total of 1199 sentences.
The reader is left to wonder what the perichromosomal compartment is for, how recruitment of the above mentioned proteins is regulated, and why.
MiR-17, -20a, and -106b target all mentioned proteins involved in this network, and from the functional interactions described, one "final" goal of this regulatory pathway seems to be the control of E2F activity.
Two previously mentioned proteins, Protein phosphatase PP2A and the zinc finger protein known as Zif, have been shown to negatively regulate aPKC [ 27, 55].
Five of the seven previously mentioned proteins, CA3, MDH2, MYL3, ETFA, and TNNT3, contributed to the statistically significant discrimination of ambulant and non-ambulant DMD patients, both in serum and in plasma (Fig 6A).
Interestingly, the effects of NO on the mentioned proteins appeared to be dose- and time-dependent; cells treated with 10 μM NO donor for 14 days exhibited the most pronounced changes in protein levels as compared to cells treated with 5 μM NO donor or cells that were treated for a shorter period of time.
Accumulative studies have demonstrated that these mentioned proteins function independently from each other [ 24], and some evidence showed the linkage of them on cell motility [ 25].
Various caspase-3 cleavage sites have been detected and mapped for three of above mentioned proteins [ 15].
All the above mentioned proteins were tagged with His-tag used for purification and with HA tag used for simple identification of the protein in the cell.
Although sponges do not possess true tissues and organs, they do possess simple varieties of the mentioned proteins [ 48, 49].
