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All mentioned pathways are known to be associated with pathogen recognition and the mobilization of the innate and adaptive immune response22,23,24.
The above mentioned pathways are likely to interact with one another, proving that the exact function of the receptor is a lot more complex, than initially thought.
Although SCAT has been associated with blood pressure and, in fact, the above mentioned pathways are strongly related to endothelial dysfunction [ 4], the significance was lost after the adjustments.
The changes in the above mentioned pathways are reciprocal to those previously associated with obesity (Dahlman et al, 2005; Mutch et al, 2009) and similar to the changes observed when obese subjects experienced weight reduction (Henegar et al, 2008; Kolehmainen et al, 2008).
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In our study, these two mentioned pathways were also found.
Three of earlier mentioned pathways were detected to be significantly affected (i.e. insulin receptor signalling [p = 0.025]; IGF-1 [p = 0.006] and PTEN [p = 0.039]; see Figure 3B), and in addition the EGF and Estrogen receptor signalling pathways.
Interestingly, all of the mentioned pathways were primarily, if not completely, enhanced by genes that were more highly-expressed in MFP vs. PAR.
Similarly, a Venn diagram for the differentiated CNV-genes from the above mentioned pathways is depicted in Figure 4B and the corresponding list of unique and shared genes for each population pair is given in Additional file 7: Table S5.
One of the possible explanations, for this lack of differential regulation of genes downstream of the mentioned pathways, is the finding of amplification at the EGFR locus (six copies) in PT4 and the biallelic loss at the PTEN locus in PT6 (both HD-type cells), which may result in stimulation of these pathways similar to the combination of monoallelic EGFR gain and PTEN loss.
On the other hand, public pathway databases with names are readily available and patterns commonly used for mentioning pathways are well understood.
The above-mentioned pathways are summarized in Figure 3B.
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