Notably, MELK expression is strongly correlated with cell proliferation, e.g., it's correlation with PCNA expression in the above-mentioned cell proliferation signature is 10th of the total 129 genes (Venet et al., 2011).
The mediators which stimulate the migration and proliferation of the mentioned cells are the growth factors, such as EGF, KGF, and TGF- α.
Furthermore, we hypothesize that, like in the solid tumors mentioned above, AQP5 may trigger cell proliferation in leukemic cells.
Among the proposed cardioprotective effects of vitamin D, reduced expression of mediators of myocardial hypertrophy, including atrial natriuretic peptides, and growth factors promoting cell proliferation were mentioned [ 10].
64 Other relevant studies did not refer to nestin expression in lung CSCs 65, 66 and only mentioned the effect of nestin on cell proliferation.
It is interesting to mention that PRDX2 has been associated to cell proliferation and cell migration by regulation of the PDGF signalling [ 67].
It was mentioned above that shedding of cadherin E resulted in increased cell proliferation.
All the genes mentioned above are known to be important in the stimulation of cell proliferation and recruitment.
(2007) applied this method to the previously mentioned data set of brain gene expression and unveiled two anticorrelated modules containing cell proliferation‐ and cell differentiation‐related proteins.
It has been mentioned that baicalin and baicalein, two flavonoid compounds, have inhibitory effects on endothelial cell proliferation, migration, and differentiation [ 11, 12].
