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As we have mentioned, activation of mPP not only produces excitation on GC but also activates inhibitory circuits in a feedforward manner.
As already mentioned, activation of the Nrf2 pathway leads to a repressed lipogenic programme in the liver of mice fed high-fat [ 30] or standard diet [ 24].
As mentioned, activation of AMP-PK can be achieved by targeting mitochondrial energy production, as it was shown with Rh123 (Fig. 6).
As mentioned, activation of P2X7 receptors is thought to induce inflammasome activation by facilitating K+ efflux and/or recruitment of the hemi-channel pannexin-1 and subsequent entry of DAMPs into the cell.
As mentioned, activation of coagulation cascade is a common and early phenomenon in the development of sepsis, and this fact supports the use of anticoagulant treatments as potentially useful interventions.
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As previously mentioned, activation and deactivation of genes participating in a specific biological process is achieved, amongst others, by the binding of TFs to cis-elements in the promoter region of affected genes.
In contrast, cells that were initially stimulated in the presence of TGF-β, did not display any of the above mentioned activation parameters and resembled unstimulated cells.
As previous agents had mentioned, activation will be done in store.
As previously mentioned, the activation of PRP forms an antibacterial platelet gel consisting of multiple active growth factors.
As mentioned earlier, activation of EGFR kinase by dimerization involves conformational changes in key regions of the N-lobe, including repositioning of a regulatory C-helix from an inactive to active conformation, and movement of the N-lobe relative to the C-lobe [11], [42].
As previously mentioned, this activation of metabolizing enzymes through Ahr may lead to the formation of toxic metabolites of the activating ligand itself.
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