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Clinically, females who receive similar cancer drugs and who do not immediately become menopausal will experience premature menopause because of the diminishment of ovarian reserve.
Postmenopausal osteoporosis (PMO) is osteoporosis that occurs after menopause because of the decrease in estrogen.
Up to 90% of young breast cancer survivors experience premature menopause because of adjuvant treatment strategies such as chemotherapy, antioestrogenic agents and ovarian ablation techniques.
Since postmenopausal osteoporosis was originally related to an increase in osteoclastic activity at the time of menopause, because of the disappearance of the oestrogen inhibitory effect on bone resorption, inhibitors of bone resorption have genuinely been considered an adequate strategy for prevention and treatment of osteoporosis.
The age distribution of breast cancer incidence in humans is usually attributed to the fact that several rate-limiting somatic mutational events are required to generate a malignant tumour (Armitage et al, 1961), with a slowing down of the carcinogenic process at the menopause because of the lower mitotic rate in postmenopausal women.
One caveat is that inhibin may not be eliminated from the tumor setting by goserelin or menopause because of breast cancer cell expression of inhibin A (in ductal carcinoma in situ) and inhibin B (in primary tumors and metastases) subunits [ 28].
Similar(53)
Orca families are matrilineal; new research reveals that orca mothers live longer after menopause because "the presence of mothers ensured greater survival of adult sons to breeding age".
Thus, there is a finite follicle store which becomes exhausted around the time of menopause because the great majority is lost by atresia instead of undergoing ovulation.
A more precise formulation of what causes controversy is "motherhood after the normal age of menopause": because what the objectors are concerned about is not the presence or absence of menstruation itself, but advanced age and questions of normality (Monbiot 2001).
Consider this type of therapy if you have premature menopause, because you may be at more risk of heart disease and osteoporosis.
A Forgive me for being pedantic, but obviously there is no such thing as a male menopause because the word means the cessation of periods and you can't cease what you never started.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com