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The trial reported Wednesday involved 58 men with localized high-risk disease.
Many elderly men with localized CaP receive only hormonal therapy.
However, death rates are much higher in all men with localized high-risk disease with a 31% mortality rate [ 51].
[3] The report "Role of Active Surveillance in the Management of Men With Localized Prostate Cancer" was released in 2011.
18 Nanda et al reported the results of a retrospective study including 5077 men with localized or locally advanced prostate cancer who were treated with or without a median of 4 months of neoadjuvant hormone therapy (gonadotropin-releasing hormone agonist and antiandrogen) followed by radiation therapy.
Several RCTs have documented a prolongation in DSS and/or OS when HT is added to EBRT in comparison to EBRT alone in the treatment of men with localized high-risk and locally advanced PCa [ 10- 12].
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Our research into the pathophysiology of micrometastatic dissemination and cancer recurrence has resulted in the initiation of a clinical trial for men with clinically localized and locally advanced disease.
To demonstrate the effect of 5AR inhibitors prior to localized therapy, Andriole and colleagues (2004) randomized 46 men with clinically localized prostate cancer to either dutasteride or placebo for 6 to 10 weeks prior to radical prostatectomy (Andriole et al 2004).
The appropriate therapy for men with clinically localized prostate cancer is uncertain.
To elucidate the effect of diet and comprehensive lifestyle changes on cancer risk, we are conducting a randomized, prospective clinical trial on men with clinically localized prostate cancer who have selected "watchful waiting" as primary therapy.
The recent enthusiasm for prostate cryoablation as a reasonable minimally invasive treatment option for men with clinically localized cancer is likely to result in modifications of the established surgical technique.
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