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"This study provides support for continued screening in men with genetic mutations," she said.
This will be a prospective diagnostic trial of screening for prostate cancer among men with genetic predisposition.
The primary aim of this study is to estimate the true prevalence of prostate cancer among men with genetic predisposition.
2. Sensitivity, specificity, positive and negative predictive value of: PSA, free to total PSA, prostate MRI in detecting prostate cancer among men with genetic predispositions will be calculated.
To test the accuracy (sensitivity, specificity, positive and negative predictive value) of different screening tests (PSA, free to total PSA, prostate MRI) in detecting prostate cancer among men with genetic predispositions.
3. To establish the cost effectiveness of different screening tests (PSA, free to total PSA, prostate MRI) in detecting prostate cancer and clinically significant prostate cancer among men with genetic predispositions.
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These include men born with genetic diseases or whose testes no longer function after chemotherapy.
This is the first study to show that there are differences in PSA values among men with different genetic backgrounds.
A high proportion of men with the genetic abnormality had close relatives with cancers other than prostate cancer compared with the study group that did not have a mutation.
The men with a genetic tendency toward lower BDNF levels seemed to lose their ability to perform complicated tasks at almost double the rate of the men without the variation.
A strength of this study is the unique patient cohort of men with a genetic predisposition to PrCa, in particular BRCA2 carriers who are predisposed to aggressive PrCas (Mitra et al, 2008; Narod et al, 2008; Castro et al, 2013; Castro et al, 2015).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com