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Twenty men with biochemical recurrent prostate cancer were enrolled.
Of the 56 men with biochemical failure, 30 remain on an observation policy without further treatment.
Numerous phase I and II clinical trials have studied men with biochemical recurrence (PSA only) prostate cancer after previous therapy.
Dietary intervention with isoflavone supplementation may have biologic activity in men with biochemical recurrent prostate cancer as shown by a decline in the slope of PSA.
Within the United States Alliance Clinical Trials co-operative group, a trial of 'androgen annihilation' for men with biochemical relapse is in development.
Nevertheless, the results of this study suggest biologic activity with the isoflavone diet in men with biochemical recurrent prostate cancer Our findings show that isoflavone was a well-tolerated alternative to expectant management or early ADT in men with biochemical recurrent prostate cancer.
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Fig. 4 A 62-year-old man with biochemical recurrence (PSA of 3.2), who had suspected PSMA-avid prostate bed recurrence measuring 1.0 × 0.6 cm after initial treatment with brachytherapy, seen on PSMA PET (b) and DCE images (d).
In men with a biochemical (PSA-only) recurrence after primary therapy, the timing of the initiation of ADT should be considered carefully.
Thus, as improved molecular imaging of PCa is necessary, the aim of this study was to prospectively compare the detection rate of 68Ga-PSMA versus 11C-Choline in men with PCa with biochemical recurrence using a tri-modality PET/CT-MRI system.
In a study of NHT in 378 men with localised PCa, biochemical response (i.e., PSA reduction) to NHT was a more important predictor of therapeutic benefit than the duration of NHT (Alexander et al, 2010).
The aim of this study was to prospectively compare the detection rate of 68Ga-PSMA versus 11C-Choline in men with prostate cancer with biochemical recurrence and to demonstrate the added value of a tri-modality PET/CT-MRI system.
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