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Coinciding with this improvement in learning and memory, we found that treatment resulted in decreased soluble Aβ, including Aβ oligomers, previously found to be linked to cognitive functioning.
Regarding verbal working memory, we found two patient studies.
Verbal memory (measured by Wecheler Memory Scale) was by far the most affected parameter in the study of Kharkar et al and similarly was reported to be moderate to severe in 90% of the patients studied by Arseni et al. Although we did not test verbal memory, we found significant deficits in other verbal functions (verbal fluency).
As for the correlations with the visuospatial working memory, we found significant correlations between the mean contrast values in the left SFG and performance on the 2D (r = 0.585, P = 0.022) and 3D matrix tests (r = 0.562, P = 0.029) among the late-onset blind participants.
As an example of its computational efficiency, running BlindCall on a single-core Matlab instance on an Intel i7 3610QM laptop with 2.3 3.3 GHz processor and 8 GB of memory, we found that it was able to process 1 million bases/s, or >85 billion bases/CPU day.
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Finally, we assessed whether the effect of visual memory on DM is mediated by working memory and we found that the relationship between visual memory and DM was partially mediated by working memory (27%) and that the direct effect remained significant (p=0.01).
After partialing out the effect of working memory capacity, we found that, on the memory test, participants performed worse in conditions where learning material was presented three times.
Using a social memory paradigm, we found that rejected participants exhibited better memory for other-related social behaviors, but poorer memory for self-related social behaviors in comparison to accepted participants.
Consistent with finding enhanced Bim transcription in p47phox−/− CD8+ memory lymphocytes, we found that p47phox−/− CD8+ memory lymphocytes express high levels of hypo-phosphorylated FOXO3a protein.
Regarding memory subsets, overall, HIV-patients had similar memory CD4+ counts as Healthy-control; but when we analyzed memory CD8+, we found that HIV-patients had higher counts than Healthy-control (Table 3).
Using a rodent hippocampus-dependent memory paradigm, we found that Bdnf DNA methylation levels significantly decreased while Bdnf mRNA levels increased in the epileptic hippocampus during memory consolidation.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com