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Schizophrenic patients showed decreased oxy-Hb during the false memory trials in both hemispheres.
Figures 2a and b (left) represent the activation patterns during the delay period for true correct memory trials in each group.
This finding diverges from the previous study of spatial WM by Lee et al. [13], in which they found increased rate of false memory trials in schizophrenia.
We categorized correct-and-confident trials as 'true correct memory' trials in which correct encoding and adequate maintenance are assumed to have taken place.
Among error trials, we examined 'false memory' trials in which subjects were wrong but nevertheless were highly confident of that they were right.
Considering lack of such functionally relevant deactivation in SZ group and in false memory trials in CO, less task-induced deactivation in the prefrontal area during maintenance may have contributed to maintaining false representations.
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The number of true correct memory trials was greater in CO than in SZ, with a large effect size (t(23) = 1.91, p = 0.03, 1-tailed, Cohen's d = 0.79).
We found that the discriminative power of the associative memory test was greater than for the item memory test in Trial 1, Trial 3, and total score, confirming the results of Troyer et al. (2008) [ 14] that associative memory test had advantage for identifying aMCI from normal aging in comparison to item memory.
The regions activated during the delay for true memory trials are listed in Table 2.
The regions activated during the delay for false memory trials are listed in Table 3.
Furthermore, the pattern and extent of activation is more bilateral and increased in true memory trials, whereas it is shifted leftward in false memory.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com