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While behavioral studies using several different memory tasks have provided converging evidence for an influence of 5-HTR2a human2Tyr on humemorymory performance, the underlying neural correlates have thus far been unclear.
According to the authors, findings supported the neural efficiency hypothesis and suggested that the connections between brain areas of well-educated subjects engaged in working memory tasks have less small-world characteristics than those of less-educated volunteers.
14 Morris water maze and episodic-like memory tasks have been previously detailed.
For instance, hippocampal, septohippocampal or reticular thalamic nucleus lesions, which had detrimental effects on performances in many memory tasks, have been shown to enhance two-way active avoidance performance [ 47- 51].
Higher basal [Ca2+]i, due to delayed Ca2+ clearance after stimulation of neuronal activity, impaired synaptic transmission and reduced performance in spatial learning and memory tasks have all been observed in NCX3 knockout mice (Molinaro et al., 2011), a situation analogous to proteolytic inactivation of NCX3.
According to Arnsten et al. electrophysiological recordings of PFC neurons in monkeys performing working memory tasks, have shown that PFC neurons are able to hold modality-specific information "on-line" over a delay period and use this representational information to guide behaviour in the absence of environmental cues.
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Moreover, cortisol-related impairment in prefrontal-dependent working memory tasks has been reported (Lupien et al. 1999; Elzinga and Roelofs 2005; Young et al. 1999; Oei et al. 2006; Wolf et al. 2001a).
On the other hand, cerebellar activity during working memory tasks has been demonstrated [ 31], forming part of a circuit that includes prefrontal (Brodmann areas 6, 9, 44, and 46), parietal, temporal and anterior cingulated cortices, and cerebellum [ 32- 35].
It is interesting to note that the increased MTL-mPFC theta phase coupling observed at decision points during rodent spatial working memory tasks has a parallel in recent observations of increased theta coupling between these regions during human decision-making tasks (Guitart-Masip et al., 2013).
Whereas the use of hippocampus-dependent episodic memory tasks has allowed others to demonstrate impairments in Met carriers, we have shown that the effect of the Met allele on the hippocampus makes a participant less likely to use a spatial strategy when another option is available to them.
Cerebellar activation during verbal working memory tasks has predominantly been attributed to subvocal articulatory rehearsal processes (Ackermann, Mathiak, & Riecker, 2007; Ben-Yehudah & Fiez, 2008; Ben-Yehudah, Guediche, & Fiez, 2007; Chiricozzi, Clausi, Molinari, & Leggio, 2008; Hayter, Langdon, & Ramnani, 2007; Stoodley & Schmahmann, 2009).
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