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(a) Fear conditioning (reflected by % freezing during the memory retention test) was significantly impaired in naive and sham-operated Tg2576 mice, compared with naive WT mice.
They received intra-VTA infusions of lidocaine or saline immediately before training, after training or before a memory retention test.
However, inactivation of the VTA immediately prior to the memory retention test failed to alter either step-through latency or the amount of time spent in the dark compartment.
The procedures for memory retention test are described below.
The novel object recognition and memory retention test was used to examine recognition memory.
The memory retention test was performed 32 days after the PC lesion.
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The total distance traveled did not differ between groups during the memory retention tests (Figures 7C and 7D).
CNS function differs between workers, as measured in laboratory learning and memory retention tests (see citations [25], [26] for recent reviews).
Importantly, the numbers of retrieved patterns in the context recall tests were tightly correlated with behavioral performances in the memory retention tests at both the individual and group levels, thereby meeting the criteria of functional readout.
For example, this is no evidence in explicitly linking place cell replay to cue-induced behavioral memory readout at memory retention tests (e.g. to demonstrate that place cell firing would replay upon presenting a recall cue with the rats not in running motion, and then to correlate such replay with behavioral scores of spatial memories).
Data of memory retention tests and the genotyping array available from the Dryad Digital Repository: 10.5061/dryad.10.5061/dryad
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