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An important objective of functional neuroimaging research is to identify neuroanatomical correlates of memory processes such as encoding and retrieval.
The hippocampal neurogenesis can be directly involved in variety of cognitive processes; decreased neurogenesis negatively affects certain learning and memory processes such as spatial memory [51], [53].
Moreover, we also explored other learning and memory processes, such as the recent memory, as tested in the passive avoidance paradigm.
Memory processes, such as acquisition, consolidation and retrieval are temporally regulated events.
In contrast, the posterior DLPFC-posterior parietal network was more related to the execution of movement as well as working memory processes such as the n-back task.
Sensitization is distinct from, but interactive with, other neurobiological learning and memory processes such as conditioning and habituation (compare adaptation or tolerance).
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It has been well established that associative memory has been found disproportionately impaired in contrast to item memory in aMCI population [ 14, 15] in terms of the overall performances, but little is known about the specific aspects of the memory process (such as learning rate) that show differences between aMCI and healthy controls.
Specific cortical sites are activated by remote memory processes and such activation is absent in mice with remote memory deficits (e.g. Frankland et al., 2004).
Neuronal-microglial interactions in the medial temporal lobes (MTL) are believed to regulate memory related processes such as LTP and neurogenesis.
Under these conditions it is not known whether the observed brain activity reflects the studied memory process as such or only the memory process in the given modality.
We used fMRI to test if minocycline modulates healthy memory processes, and whether such effects are principally mediated by MTL memory systems.
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