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A spatial memory probe test revealed that memory for the escape platform location of the acetylcholine-grafted rats was significantly better than that of rats with control grafts and matched the performance of young controls.
After the last training trial, spatial reference memory probe trials were conducted at 1.5 and 24 h in order to evaluate short- and long-term memory performances, respectively.
As illustrated in Figure 1, each trial started with the presentation of face memoranda (3.5 s), which subjects were instructed to encode and then maintain into WM during the delay interval between the offset of the memoranda and the onset of the memory probe (12.5 s).
The memory probe digit was a match on 50% of trials selected at random.
After a 500-ms ISI, a single object (the memory probe) was centrally presented.
A memory probe was then presented for 3 s (or until a response was made).
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The hidden platform training was carried out over 5 days (four trials per day) and followed by a memory retention probe test on day 6.
Moreover, during the memory probe-trial sham-exposed animals showed the expected preference for the target quadrant, while the exposed animals showed no preference, indicating that the exposed mice had deficits in consolidation and/or retrieval of the learned spatial information.
They found that memory probes that were triggered during decreased PHC activity levels were remembered significantly better than memory probes that were triggered during high PHC activity levels.
The memory probes were included to ensure that participants were engaging in the task.
Interviewers trained in the use of calendars and memory probing improved the long term recall of PA, hinting at approaches that could be used in standardized survey questions such as calendar based prompts.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com