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A recent study showed that formation of the influenza-specific B cell memory pool requires autophagy (Chen et al., 2014).
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These observations imply that selection of GC B cells into the long-lived PC pool requires an additional checkpoint for autoreactivity that is not required for memory B-cell fate.
To use the only swimming pool requires a trip outdoor.
The entire FP processing pipeline could be run on parallel nodes with modest memory capacity (less than 8 GB) and each pool required less than 6 CPU hours; the assembly part usually took less than 0.5 hours.
However, we found that for the different pathogen environments infinite memory pool sizes are not required.
We tested this idea by immunizing Ig μ transgenic mice in a manner designed to select B cells that required only one VH mutation for a switch in antigenic specificity and recruitment into the memory pool.
Use a merging approach to create the combined memory pool.
Afterwards, the best match from the memory pool is selected and added to the artificial recognition ball (ARB) pool.
The inserted data size consumes the entire memory pool of the single node and cluster shards.
A processor can access the other processors' memory pool via a dedicated processor-to-processor interconnect.
Actual deallocation of memory can be deferred until the lifetime of the memory pool ends.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com