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Mucosal administration of human IL-15 cDNA enhanced both humoral and cellular immune responses during memory phase of vaccinated mice (Toka et al., 2004; Toka and Rouse, 2005).
We aimed at investigating rapid effects of plasma cortisol elevations on the episodic memory phase of encoding or retrieval, and on the strength of the memory trace.
Collectively, these studies show that CD4+ T cells can synthesize anti-viral CCR5 ligands during the memory phase of an adaptive immune response, although CD8+ T cell subsets might be the predominant source of these molecules at this point in the adaptive immune response.
However, no significant differences were observed in the performance of the memory phase of the test (removal session) nor in a step-down passive avoidance task, thus suggesting that once learning has been established, the animals are able to consolidate the information in the longer term.
Once habituation was completed, the working memory phase of training began.
However, no such novelty applies in the memory phase of our task as stimuli and task requirements are as for the learning phase.
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Mice that are transgenic (Tg) for T cell receptor (TCR) expression are used extensively to analyze longitudinal T cell responses during effector and memory phases of the T cell response.
No significant differences were noted in parallel bars, tremor, or in the learning and memory phases of the Morris water maze (not shown).
In addition, neither could the specific probabilistic choice deficit be explained by generic failure of executive function such as perseveration, as a perseverative tendency would affect performance in both the learning and memory phases of our task as well as the integration phase.
Appropriate experimental design allows separation of motor, sensory and memory storage phases of mental processes.
Research is ongoing to find out whether this deliberate forgetting occurs at the storage phase of memory, perhaps via suppressed rehearsal, or later, at the retrieval phase.
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