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On the spatial working memory delayed-match-to-sample water maze, the highest E1 dose impaired memory performance during acquisition and after delay challenge.
Our results show that bilateral tDCS over the PPC significantly enhanced recognition memory performance during immediate recognition and possibly have an effect on post-learning processing.
This confirms that the reduction in false memories was not because subjects had an overall poor memory performance during active stimulation.
This interpretation found further support in findings of hampered memory performance during the perception of angry, but not happy background music in alexithymia [40].
Vermeulen and colleagues found that during the presentation of angry, but not happy background music, high scorers on alexithymia recognized fewer anger and joy words than low scorers, indicating hampered memory performance during angry music perception associated with alexithymia [40].
Unexpectedly, working memory performance during neuropsychological testing was not associated with activation in any of the ROIs for the N-back working memory fMRI task.
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To test whether Post-Pre2 perfusion changes were correlated with individual memory performances during the cued associative recall task, two separate regression analyses were computed for recent and older correct responses.
Thus, after chronic stimulation, we found significant improvement in both the short- and long-term memories in the NOR test, as well as the spatial memory performances during the MWM task as compared to the sham.
Relative to placebo, results in the triazolam condition (n = 6) revealed significantly impaired memory performance, and deactivation during encoding in a subset of areas shown previously to be associated with encoding (anterior cingulate cortex, cerebellum, and precuneus).
Andrews et al. found tentative evidence to suggest that DLPFC tDCS applied concurrently with a cognitive task may provide more robust effects on subsequent working memory performance that stimulation during rest.
Yet, despite these findings linking HF to the DMN, the current results clearly show that, at least during memory performance, the coherence between DMN and HF is not universal, but dependent on the type of memory operation, either encoding or retrieval.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com