We report on memory outcome in a sample in whom we previously reported long-term improvements in intellectual function (Skirrow et al., 2011).
We devised an algorithm using asymmetry indices of preoperative memory encoding activation in the anterior medial temporal lobe, language lateralization and performance on preoperative neuropsychological assessment to predict clinically significant postoperative verbal and visual memory outcome in individual subjects.
Together, these results suggest that specific item encoding (e.g., hippocampus) and source encoding (e.g., PFC) processes play a critical role in determining true and false memory outcome in misinformation paradigms.
Linear regression analysis was used to determine clinical predictors [age at seizure onset, duration, current seizure status, lesion type (DNT or hippocampal sclerosis), current anti-epileptic medication] of FSIQ-independent memory outcome in the surgical cohort.
The current postoperative follow-up study was concordant with these findings as greater pre- than postoperative activation within the ipsilateral posterior hippocampus correlated with better verbal memory outcome in patients with left TLE.
Furthermore, it is not yet known if the extent of resection to both the hippocampus and the temporal neocortex is as functionally relevant to memory outcome in children as it is for adults.
The same authors postulated that neither medial resection length nor resected hippocampal volumes influenced postoperative seizure outcome whereas resection of larger hippocampal volumes resulted in poorer verbal memory outcome in patients with TLE who underwent selective amygdalo-hippocampectomy (Helmstaedter et al., 2011 b ).
Moderate effects on memory outcomes were identified in seven trials.
In contrast relative effect sizes on memory outcomes following memory strategy training ranged from.88 to -1.18.
Patients' pattern of results and significant correlations between TP tasks and memory outcomes suggest that TP impairments are related to memory impairment in schizophrenia.
