Therefore, transgenerational heritability of gene expression in the germ line requires a memory of prior expression in the parental germ cells, otherwise it is targeted as a foreign invader by the genome's immune surveillance systems, which include piRNAs.
These data demonstrate that epigenetic memory of FLC expression is stored not in trans but in cis.
H3K36me3 regulates transcription of active euchromatin, alternative splicing, DNA repair, and transmission of the memory of gene expression from parents to offspring.
The striking changes in nuclear organization that arise during differentiation, and which distinguish populations of differentiated cells, raise the question of whether subnuclear position plays a role in cell-type memory of gene expression patterns.
Methylation of H3K36 is a key histone mark and has been widely associated with active chromatin but also with transcriptional repression, alternative splicing, DNA replication and repair, DNA methylation and the transmission of memory of gene expression from parents to offspring during development (reviewed in [ 41]).
However, it remains unclear whether this inheritance can direct long-term memory of individual gene expression states (cis memory) or instead if local chromatin states are dictated by the concentrations of diffusible factors (trans memory).
The first component would reflect a 'gene expression memory' of the tumor of origin (similar expression calls for cells from the same origin, different calls for those from different origins).
But they could equally have reflected his knowing about these events, rather than actual memories of them — expressions of "semantic" memory rather than "event" or "episodic" memory.
However, E2 replacement protected ovariectomized female rats from the disruption of memory expression following a start position change in response-learners.
In a rare political intervention, the Nelson Mandela Centre of Memory issued an "expression of concern" about the bill and proposed four amendments.
(D) Representative dot plots showing the frequency of memory cells with expression of CCR7.
